 | | DRUG: Esomeprazole magnesium | |
| Entry |
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| Name |
Esomeprazole magnesium (USP);
Esomeprazole magnesium hydrate (JAN);
Esomeprazole magnesium trihydrate;
Nexium (TN) |
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| Product |
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| Generic |
ESOMEPRAZOLE DR (Direct_Rx), ESOMEPRAZOLE MAGNESIUM (A-S Medication Solutions), ESOMEPRAZOLE MAGNESIUM (A-S Medication Solutions), ESOMEPRAZOLE MAGNESIUM (A-S Medication Solutions), ESOMEPRAZOLE MAGNESIUM (A-S Medication Solutions), ESOMEPRAZOLE MAGNESIUM (A-S Medication Solutions), ESOMEPRAZOLE MAGNESIUM (Advanced Rx Pharmacy of Tennessee), ESOMEPRAZOLE MAGNESIUM (Advanced Rx Pharmacy of Tennessee), ESOMEPRAZOLE MAGNESIUM (Amneal Pharmaceuticals LLC), ESOMEPRAZOLE MAGNESIUM (Aphena Pharma Solutions - Tennessee), ESOMEPRAZOLE MAGNESIUM (Ascend Laboratories), ESOMEPRAZOLE MAGNESIUM (Asclemed USA), ESOMEPRAZOLE MAGNESIUM (Biocon Pharma Inc.,), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Camber Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Direct Rx), ESOMEPRAZOLE MAGNESIUM (Dr. Reddy's Laboratories), ESOMEPRAZOLE MAGNESIUM (Granules Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Graviti Pharmaceuticals Private Limited), ESOMEPRAZOLE MAGNESIUM (Lake Erie Medical DBA Quality Care Products LLC), ESOMEPRAZOLE MAGNESIUM (Major Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Medsource Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Mullan Pharmaceutical), ESOMEPRAZOLE MAGNESIUM (Mylan Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NorthStar Rx LLC), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (PD-Rx Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Proficient Rx LP), ESOMEPRAZOLE MAGNESIUM (Proficient Rx LP), ESOMEPRAZOLE MAGNESIUM (Proficient Rx LP), ESOMEPRAZOLE MAGNESIUM (Proficient Rx LP), ESOMEPRAZOLE MAGNESIUM (Quality Care Products), ESOMEPRAZOLE MAGNESIUM (Quallent Pharmaceuticals Health LLC), ESOMEPRAZOLE MAGNESIUM (REMEDYREPACK), ESOMEPRAZOLE MAGNESIUM (REMEDYREPACK), ESOMEPRAZOLE MAGNESIUM (Solco Healthcare US LLC), ESOMEPRAZOLE MAGNESIUM (Somerset Therapeutics), ESOMEPRAZOLE MAGNESIUM (Sun Pharmaceutical Industries), ESOMEPRAZOLE MAGNESIUM (Torrent Pharmaceuticals Limited) |
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| Formula |
(C17H18N3O3S)2. 3H2O. Mg
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| Exact mass |
766.2305
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| Mol weight |
767.1671
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| Structure |
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| Simcomp |
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2329 |
| Product (DG00023): | D01984<JP/US> D04056<US> D10120<US> D11114<US> |
| Product (mixture): | D11576<US> |
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| Efficacy |
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor |
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| Disease |
Gastroesophageal reflux disease [DS: H01602] Gastric ulcer [DS: H01634] H. pylori eradication [DS: H00320] Zollinger-Ellison syndrome [DS: H01522] |
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| Comment |
Benzimidazole derivative
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC05 Esomeprazole
D01984 Esomeprazole magnesium (USP) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Proton Pump Inhibitors
Esomeprazole
D01984 Esomeprazole magnesium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
232 Peptic ulcer agents
2329 Others
D01984 Esomeprazole magnesium (USP); Esomeprazole magnesium hydrate (JAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00023 Esomeprazole
D01984 Esomeprazole magnesium
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00023 Esomeprazole
D01984 Esomeprazole magnesium
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00023 Esomeprazole
D01984 Esomeprazole magnesium
Drug classes [BR:br08332]
Gastrointestinal agent
DG01646 Proton pump inhibitor (PPI)
D01984 Esomeprazole magnesium
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D01984 Esomeprazole magnesium (USP) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D01984
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01984
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01984
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D01984
Rx-to-OTC switch list in the USA [br08315.html]
D01984
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00023 Esomeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00023 Esomeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00023 Esomeprazole
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| Other DBs |
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| KCF data |
ATOM 52
1 C8x C 20.3918 -19.3472
2 C8y C 20.3918 -20.7493
3 C8x C 21.6097 -21.4467
4 C8x C 21.6097 -18.6427
5 C8y C 22.8207 -19.3472
6 C8y C 22.8148 -20.7527
7 N5x N 24.1500 -21.1904
8 C8y C 24.9834 -20.0554
9 N4x N 24.1593 -18.9137 #-
10 S4a S 26.3731 -20.1218
11 C1b C 27.0706 -21.3335
12 C8y C 28.4655 -21.3335
13 C8y C 29.1663 -22.5426
14 C8y C 30.5613 -22.5426
15 C8y C 31.2554 -21.3335
16 C8x C 30.5613 -20.1245
17 N5x N 29.1663 -20.1245
18 C1a C 32.6572 -21.3335
19 O2a O 31.2587 -23.7576
20 C1a C 32.6608 -23.7576
21 C1a C 28.4619 -23.7576
22 O3c O 27.0682 -18.9053
23 O2a O 19.1841 -21.4472
24 C1a C 17.9687 -20.7505
25 Z Mg 36.7654 -19.6553 #2+
26 O0 O 38.0919 -22.0340
27 C8x C 20.3918 -19.3472
28 C8x C 21.6097 -18.6427
29 C8y C 22.8207 -19.3472
30 C8y C 22.8148 -20.7527
31 C8x C 21.6097 -21.4467
32 C8y C 20.3918 -20.7493
33 O2a O 19.1841 -21.4472
34 C1a C 17.9687 -20.7505
35 N5x N 24.1500 -21.1904
36 C8y C 24.9834 -20.0554
37 S4a S 26.3731 -20.1218
38 C1b C 27.0706 -21.3335
39 C8y C 28.4655 -21.3335
40 C8y C 29.1663 -22.5426
41 C8y C 30.5613 -22.5426
42 C8y C 31.2554 -21.3335
43 C8x C 30.5613 -20.1245
44 N5x N 29.1663 -20.1245
45 C1a C 32.6572 -21.3335
46 O2a O 31.2587 -23.7576
47 C1a C 32.6608 -23.7576
48 C1a C 28.4619 -23.7576
49 O3c O 27.0682 -18.9053
50 N4x N 24.1593 -18.9137 #-
51 O0 O 38.0919 -22.0340
52 O0 O 38.0919 -22.0340
BOND 52
1 2 3 1
2 23 24 1
3 8 10 1
4 3 6 2
5 10 11 1 #Up
6 5 4 2
7 11 12 1
8 4 1 1
9 12 13 2
10 13 14 1
11 14 15 2
12 15 16 1
13 16 17 2
14 17 12 1
15 1 2 2
16 15 18 1
17 5 6 1
18 14 19 1
19 6 7 1
20 19 20 1
21 7 8 2
22 13 21 1
23 8 9 1
24 10 22 2
25 9 5 1
26 2 23 1
27 32 31 1
28 33 34 1
29 36 37 1
30 31 30 2
31 37 38 1 #Up
32 29 28 2
33 38 39 1
34 28 27 1
35 39 40 2
36 40 41 1
37 41 42 2
38 42 43 1
39 43 44 2
40 44 39 1
41 27 32 2
42 42 45 1
43 29 30 1
44 41 46 1
45 30 35 1
46 46 47 1
47 35 36 2
48 40 48 1
49 36 50 1
50 37 49 2
51 50 29 1
52 32 33 1
BRACKET 1 16.3800 -24.7100 16.3800 -17.6400
1 34.1600 -17.6400 34.1600 -24.7100
1 2
ORIGINAL 1 1 4 5 6 3 2 23 24 7 8 10 11 12 13 14 15
1 16 17 18 19 20 21 22 9
REPEAT 1 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
1 43 44 45 46 47 48 49 50
2 36.1900 -22.9600 36.1900 -21.0700
2 38.5000 -21.0700 38.5000 -22.9600
2 3
ORIGINAL 2 26
REPEAT 2 51 52
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